Koksican 120g
Kokcisan is produced by a conventional fermentation process using a highly selected strain of the micro-organism Streptomyces albus forming typical white colonies.
For the fermentation process, vegetable oil, soybean flour, corn starch, calcium carbonate and different minerals are used.
On completion of the fermentation the broth is treated with sodium hydroxide (to convert the salinomycin molecule to the more stable sodium salt) and inert carriers (e.g. calcium carbonate) are added.
Treated fermentation broth is spray dried. The obtained salinomycin sodium concentrate represents the starting material for the final Kokcisan formulation, using excipients, such as calcium carbonate. Granulation is performed on dedicated line, using the wet granulation principle with sucrose as the binder. The granulate is then dried and sieved; only the specified particle size range is collected.
The whole production process is automatised and utilises the most advanced technology complying with the GMP, ISO, FDA and HACCP directions and rules.
COCCIDIOSIS IN BROILERS
Coccidiosis remains one of the most important diseases in commercial poultry production. It is a disease caused by protozoan parasites which invade and multiply within the epithelial cells lining the intestine. In chickens, these parasites are from the Eimeria genera. Seven Eimeria species are recognised to affect broiler chickens: E. acervulina, E. maxima, E. tenella, E.brunetti, E. necatrix, E. mitisand E. praecox.
All species of coccidia are pathogenic, although some of them show a lesser degree of pathogenicity than others. The highest mortality is associated with E. Tenella and E. necatrixinfections in broiler chickens. Infections due to the other species of coccidia result in reduced weight gain, anorexia, dehydration, secondary infections, reduced absorption of nutrients, and they may also enhance the occurrence of other diseases.
The incidence of coccidiosis does, however, not depend solely on the number of undigested oocysts. There exist several other important factors linked to the production technology, which may have an important impact on the incidence of the disease. These include population density, the size of the broiler farm, litter quality, zoohygienic conditions and the previous use of coccidiostats. Other factors that may have an impact on the occurrence of the disease include lighting schedule, breed type, biosecurity, other viral and bacterial diseases, the presence of mycotoxins in feedingstuffs, and locomotor diseases.
For a reliable clinical diagnosis of coccidiosis under conditions of intensive rearing of broiler chickens, close attention should be paid not only to the parasitological examination for detection of oocysts in feces, litter and intestinal wall, but also to the localisation and characteristic features of intestinal lesions.
WITHDRAWAL PERIOD
Birds must not be slaughtered for human consumption during treatment and for at least three days after the last treatment.
SAFETY RECOMMENDATIONS REGARDING THE USE
Dangerous for equines and turkeys.
This feedingstuff contains an ionophore: simultaneous use with certain medicinal substances (e.g. tiamulin) can be contrain-dicated.
Chickens for fattening should not be treated with products containing tiamulin while receiving, or for at least seven days before or after receiving feed containing Kokcisan 120G. Severe growth depression or death may occur.
STORAGE
Kokcisan should be stored in original packaging in a dry and dark place at a temperature below 30°C. It should be protected from moisture and light.
PRECAUTIONS IN HANDLING OF KOKCISAN
Strict protection measures are recommended in the production plant: ventilation of premises, wearing of overalls, gloves and glasses and a face mask with a respiratory filter for the protection of operators to avoid direct contact with the product or inhalation.
SUPPLY
25-kg net in polythene-lined multi-walled paper bags
