Maxiban
Maxiban is an anticoccidial premix containing 36 grams of narasin and 36 grams of nicarbazin per pound. This approved product is an ionophore and chemical combination. This combination maximizes the benefits of each component and may minimize their potential negatives. Research trials have documented Maxiban’s effect on coccidia is greater than that achieved by either compound alone and exceeds the expected additive benefits for controlling coccidia. This synergistic relationship between the product’s two active ingredients classifies Maxiban as a potentiated chemical.
Impact of Maxiban on coccidial populations
The coccidial population within the intestine of Maxiban-treated birds affected by the narasin component can be divided into three groups. The first are those parasites narasin will kill by disrupting osmotic balance, resulting in cell lysis. The second group consists of parasites narasin “damages,” resulting in depleted cellular energy reserves. This group, while still alive, continues through its life cycle in a severely compromised state. The third group consists of parasites escaping the effect of the ionophore and progressing toward maturity. There are several phases in the coccidia life cycle requiring the parasite to invade the cells of the bird’s intestinal wall where nicarbazin is active. Nicarbazin quickly kills the energy-depleted parasites and the majority of all surviving coccidial organisms. Immunity is elicited as these organisms cycle through the cellular phases, but the majority are prevented from completion of their life cycle due to the effect of nicarbazin. Maxiban is recommended for use in the starter/grower to 28 days or beyond. Other ionophores, such as CobanT or MontebanT, are often used following Maxiban. Maxiban can be incorporated into well-designed anticoccidial programs to maintain product/program efficacy while maximizing performance.
Key points
• Maxiban is a potentiated chemical — a combination of narasin and nicarbazin
• Maxiban kills coccidia by depleting the parasite’s energy through two different paths
• The synergistic effect increases coccidial control while reducing potential resistance
• The synergistic effects of these dual modes of action also allow less drug exposure
No withdrawal period is required when this drug is used according to the label.
