SOLUDOX
500 mg/g, water soluble powder for pigs
Target species
Pigs.
Composition
Active substance:
Doxycycline hyclate 500 mg/g
Pharmaceutical form
Powder for oral solution.
Indications for use
For the treatment of the clinical signs associated with porcine respiratory disease caused by Actinobacillus pleuropneumoniae, Pasteurella multocida, and Mycoplasma hyopneumoniae susceptible to doxycycline. Resistance against doxycycline may vary. Therefore the use of the product should be based on culture and sensitivity of micro-organisms from diseased cases on farm or from recent previous experience on the farm.
Contraindications
The use of doxycycline in animals with an impaired liver function should be avoided.
Amounts to be administered and administration route
Administration orally with the drinking water. The recommended dose in pigs is 12.5 mg doxycycline hyclate per kg body weight per day for 4 days. If no improvement in clinical signs is seen within this time, the diagnosis should be reviewed and treatment changed. In case of severe infections the medication period may be prolonged for a maximum of 8 days as determined by the attending veterinary surgeon. Based on the dose to be used, and the number and weight of the animals to be treated, the exact daily amount of product can be calculated. The use of suitably calibrated weighing equipment is recommended if part packs are used. The daily amount is to be added to the drinking water such that all medication will be consumed in 24 hours. Medicated drinking water should be refreshed or replaced every 24 hours. It is recommended to prepare a concentrated pre-solution - approximately 100 grams product per litre drinking water - and to dilute this further to therapeutic concentrations if required. Alternatively, the concentrated solution can be used in a proportional water medicator. To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing. The uptake of medicated drinking water depends on the clinical condition of the pigs. In order to obtain the correct dosage the concentration of doxycycline has to be adjusted accordingly.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
During preparation and administration of the medicated drinking water, skin contact with the drug and inhalation of dust particles should be avoided. Therefore it is recommended to wear impermeable gloves e.g. rubber or latex and an appropriate dust mask e.g. disposable half-mask respirator conforming to European Standard EN149 when applying the product. If you know you are allergic to the tetracycline class of antibiotics, special care should be taken when handling this product or the medicated solution. In the event of eye contact, rinse the eye with copious amounts of clean water and if irritation occurs, seek medical attention. In the event of accidental ingestion, seek medical advice. Wash hands and contaminated skin immediately after handling the product.
Special precautions for use in animals
Due to likely variability (time, geographical) in susceptibility of bacteria for doxycycline, bacteriological sampling and susceptibility testing are recommended.
Adverse reactions (frequency and seriousness)
None known.
Use during pregnancy or lactation
In the absence of specific studies the use of the product is not recommended during pregnancy or lactation.
Interactions with other veterinary medicinal products and other forms of interaction
Do not combine with antibiotics that are bacteriocidal like penicillins or cephalosporins.
Solubility of doxycycline is pH dependent. Precipitation will occur in an alkaline solution. This product should therefore not be mixed with other products.
Overdose (symptoms, emergency procedures, antidotes) if necessary
Overdoses up to 1.6 times the label recommended dose resulted in no clinical signs that could be attributed to treatment.
Withdrawal periods
Meat: 4 days
